Severe Neutropenia Associated With Hypersplenism and Portal Hypertension: Does it Predispose to Increased Infection Episodes?

Background: Neutropenia is reduction in the absolute number of neutrophils blood circulation. Common causes include increased destruction, reduced production, or excessive splenic sequestration. can be mild (Absolute Neutrophil Count (ANC) 1000-1500/L), moderate (ANC 500-1000/L), severe <500/L). Patients with neutropenia are presumed to at risk life-threatening infections. There lack information on following hypersplenism and portal hypertension. Methods: We undertook this observational study patients ANC <1500/L liver disease hypertension from January 2017 till April 2019. Results: identified 15 neutropenia. Mean age 33.13 (range 17-68) years. The average duration was 4.6(range 1-17) mean 632 (248-1152) cells/L. Mild, seen 1,8, 6 respectively. hemoglobin, total leucocyte count platelets were 7.96 (4.4-13.1) g/d, 1305 (550-2910) /L 0.47 (0.15-1.13) Spleen size 18.2 (9-23) cm. bilirubin, AST ALT levels 1.63 (0.2-4.3) mg/dl, 47.2 (20-157) IU/L 34.6 (14-59) All (except one) had an infection free follow-up no admission due infection. Only 1 patient 446/L) Wilson (WD) admitted twice, once for candidemia other rickettsial infection; both episodes resolved standard therapy. Cause disease: EHPVO=7, NCPF=4, Alcoholic Liver disease=2, congenital hepatic fibrosis=1 WD=1. WD over 4 years follow up developed SBP, urinary tract pneumonia, which ascribed progression disease. rose normal (>1500/L) each infectious occasion. Conclusion: may rarely complicate hypersplenism, particularly EHPVO NCPF. Contrary perception, not a harbinger mortality/morbidity